Measuring Food Sensitivities using the Food Inflammation Test (FIT Test)
Food sensitivities and related diseases affect at least 100 million people worldwide and cause a wide variety of illnesses ranging from skin rashes and headaches to chronic intestinal diseases. The prevalence of food sensitivities of the general population has increased by more than 50% in recent years. Delayed food sensitivities can occur up to 72 hours after ingestion, making it difficult for a patient to pinpoint which foods are causing reactions.
Understanding Food Sensitivities
Any food antigen entering the blood stream can produce symptoms associated with food sensitivities. Most food antigens enter the blood stream through the intestinal epithelium and stimulate the production of IgG antibodies. IgG antibodies bind to the food antigens that are free in the blood or that have deposited in tissues and form immune complexes (IC). The immune complexes activate complement C3 which becomes covalently linked to the IgG forming IC-C3b. Ultimately, the C3b on the IC is cleaved forming IC-C3d. During this process, C3a is released which causes smooth muscle contraction and has a potent vascular effect. Under normal circumstances, circulating IC-C3b bind to the CR1 receptors on red blood cells and are cleared from the circulation in the liver and spleen. Continued production of antibody formation of IC may result in deposition of IC in tissues which results in activation of the terminal complement pathway C5-9 on the surface of the tissue causing cell lysis and increased inflammation.
The Food Inflammation Test (FIT Test) Improves Sensitivity by Generating Two Signals
It is useful to test for food sensitivities when a patient has chronic symptoms, including digestive issues, infertility, fatigue, arthritis, cancer, in addition to other lasting problems. The measurement of both IgG and Immune Complex containing C3d simultaneously is the key to assessing food sensitivities. Measuring both IgG and IC-C3d simultaneously generates twice the signal which improves the sensitivity over other tests which employ a conventional conjugate that measures only IgG.
Benefits of the FIT Test
- The FIT Test employ a unique method that detects both IgG antibody and immune complexes.
- Measuring IgG and immune complexes together increases the sensitivity over other tests which only measure IgG alone.
- The FIT Test measures the sensitivity to 132 foods, colorings, and additives spanning all major food groups.
- Food elimination based on the FIT Test reduces symptoms and is an effective tool in patient care.
What is Zonulin?
Zonulin is a key biomarker for intestinal permeability. It is the only regulator of intestinal permeability that is reversible. Zonulin is one of the 3 ways to test for a leaky gut.
What is leaky gut?
Having leaky gut means the functions of the intestinal barriers have stopped working properly. The intestinal lining is essentially a wall of tightly joined cells that open and close when necessary, zonulin remotely controls the opening of tight junctions between the cells. If too much zonulin is produced the tight junctions remain open.
Why test using Zonulin?
Measuring zonulin can help assess a leaky gut. If zonulin can be measured in a patient’s blood, there is evidence of tissue damage. If zonulin is present there is more than 95% confidence that there is a loss in intestinal function.