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Regenerative Medicine


Regenerative Cellular Therapy



Cord Blood Regenerative medicine offers much promise for those suffering from several disease states. It is a method of using our own natural healing properties in living a better quality of life.

Regenerative cells are presently the largest target in the regenerative medicine area. Regenerative cells are naive cells that have the ability to divide indefinitely. They may functionally change into any cell in our body and can integrate into the target tissue, either in the presence or absence of damage. Regenerative cells are " undifferentiated " cells, which allow them to develop into another type of cell that is required to repair or replace damaged tissue. Regenerative cell therapy can repair tissue that is too damaged to heal on their own. Regenerative cells can stimulate the formation of cartilage, tendon, ligaments, bone, and fibrous connective tissue.

Regenerative cell therapy is in the spectrum of cutting edge therapeutic techniques used to naturally treat the cause of a painful condition rather than masking the symptoms. Regenerative cell therapy stimulates and accelerates your own body's natural ability to heal itself. Osteoarthritis is the most common cause of chronic joint pain. Osteoarthritis involves the entire joint, including the nearby muscles, underlying bone, ligaments, and connective tissue. In osteoarthritis, the supportive tissue called cartilage degenerates, leading to inflammation and pain. This type of arthritis is common in shoulders, hips, knees, hands, and feet. Patients will often complain of joint stiffness, throbbing, and swelling. There is no cure for osteoarthritis, but regenerative medicine therapies such as regenerative cell therapy is a new generation of treatment that has been proven to be safe, effective, and have lasting results.

Rethinking and evolving science using cutting edge technologies has led to the most potent and vibrant form of regenerative cells, umbilical cord blood-derived cellular allograft tissue.

Umbilical cord blood contains a beneficial blend of cytokines, growth factors, and regenerative cells that ensure a rich microenvironment to foster tissue regeneration and cellular growth. Cord blood regenerative medicine product contains primitive undifferentiated regenerative cells and additional growth factors that are beneficial for repair, growth, and healing. The release of growth factors that aid in the formation of new blood vessels, activation of endogenous regenerative cells, modulation of the immune system and growth of cells and tissue.

In regenerative cell therapy, new regenerative cells are introduced into the body, and their capability to differentiate - or turn into specialized cells - may allow them to repair diseased or injured tissues. They also proliferate or renew themselves many times, which can provide an ongoing supply of healthy cells. Regenerative cells are " intelligent ". They can move through the body to where they are needed and communicate with other cells. Research indicates that mesenchymal regenerative cells may offer other important therapeutic properties - including immunomodulation, anti-inflammatory functions, infection-fighting properties, and cell rescue actions. The array of benefits related to umbilical cord blood derived allografts is supported through the successful transplantation and coordination of multiple components. There is a careful orchestration in the ratios of cytokines, growth factors, exosomes, and regenerative cells naturally occurring in umbilical cord blood. This naturally occurring balance of cytokines and growth factors make umbilical cord blood a great resource for allograft tissue geared towards bone growth and tissue regeneration. Umbilical cord regenerative cells contain mesenchymal regenerative cells (MSCs).

They come from safe, reliable hospital sources via a non - invasive, simple, and painless procedure. The cord blood fluid allograft tissues are procured through fully tested and consented donors. Every donor is subjected to comprehensive infectious disease panels that surpass federal and industry standards, ensuring safe allografts. Umbilical cord-derived mesenchymal regenerative cells are provided by hospitals. and all donated cord blood is delivered directly to the lab for production. As no potentially risky or painful surgery is required, the extraction of umbilical cord blood is the least invasive and safest option of sourcing regenerative cells. Research has shown that cord blood regenerative cells are not susceptible to malignant transformation in a serum-free medium, making them safe for therapeutic use in patients.

The regenerative cells are screened in compliance with FDA, cGMP (Current Good Manufacturing Practice) standards, which regulate quality and safety in the production of medication.

Cord blood regenerative cells are strictly screened, high - quality, and sold in standardized concentrations. Using regenerative cells gives patients a wide range of benefits via therapies that can be conducted in under half an hour. Cord blood consistent concentrations allow for multiple administration in uniform, high - cell - count doses. Patients can enjoy safe, non - surgical treatments at the same time it would take them for a traditional office visit. Regenerative therapy procedures are performed as outpatient procedures. They involve the injection of concentrated regenerative cells to regenerate and heal tissues in joints, muscles, tendons, or ligaments.

These therapies can be used to treat acute or chronic pain conditions related to degenerative disease. Regenerative cells are shown to be capable of accelerating the healing process. In summary, cord blood regenerative cells, a regenerative medicine product, is one of the most unique regenerative cell / regenerative medicine products that exist today. Cord blood regenerative cells contain many factors that repair and heal various trauma and disease states. Cord blood regenerative cells play a role in angiogenesis, growth, and repair of cartilage and bone tissue, which serves well in orthopedic disease, and a wide array of autoimmune diseases. Cord blood regenerative cells = Rethinking and evolving science using cutting edge technologies.





The regenerative medicine product contains primitive undifferentiated regenerative cells and additional growth factors that are beneficial for repair, growth, and healing. In vitro studies illustrate the number of cells and cell surface markers indicative of regenerative cells. Most importantly, the release of growth factors that aid in the formation of new blood vessels, activation of endogenous regenerative cells, modulation of the immune system, and the growth of cells and tissue. The regenerative cells we are using are harvested from cord blood and tissue that has been isolated in a sterile environment and rigorously tested. The product is positive for MSC's marker CD90.

Most importantly, the regenerative medicine product we are using contains growth factors and cytokines such as vascular endothelial cell growth factor ( VEGF ) that helps restore oxygenation to tissues and cells when blood supply is inadequate, regenerative cell factor (SCF) to mediate cell survival, migration, and proliferation depending on the cell type. SCF plays a crucial role in such things as hematopoiesis, pigmentation, gut movement, and some aspects of the nervous system. The fibroblast growth factor (FGF - 2) is essential for the growth and development of bone and cartilage formation and interleukin 1 receptor antagonist (IL - 1ra) is responsible for controlling the inflammatory response that occurs in many diseases and trauma states. Many more growth factors are included.

Ethically harvested cells


At the time of birth, a specialized nurse enters the delivery room to carry out the extraction procedures. Our product, voluntarily donated human umbilical cord of healthy full-term babies was harvested and processed in a sterile, FDA - compliant and AABT - compliant laboratory. We never, ever purchase cord blood from foreign countries in bulk, as many of our competitors do. Our professional relationship with our local California hospitals is paramount. With the mother's informed consent, the umbilical cord is clamped off when the baby is born. This preserves the blood in the cord. Besides the blood in the cord, within the umbilical cord is a gelatinous substance, Wharton's jelly. Cells in Wharton's jelly express several regenerative cell genes, including telomerase. Wharton's jelly is therefore a potential source of adult regenerative cells. Wharton's jelly-derived mesenchymal regenerative cells may have an immunomodulatory effect on lymphocytes. As a mucous tissue, it protects and insulates the umbilical blood vessels. Hence, the umbilical cord content we utilize contains the cord blood & Wharton's jelly, referred to as tissue. Many companies only utilize cord blood. Our distinction of an umbilical cord-derived product containing both cord blood and Wharton's Jelly is superior to most other cord blood companies.

Donor eligibility is carefully assessed in accordance with AATB standards as required by the FDA. A donor's medical history and social history is reviewed and an interview is performed in accordance with FDA CFR 21 , 1271 (n). Tissue from donors who engaged in high risk behaviors and relevant communicable diseases are excluded. Screening also includes a physical health assessment, serology for evidence of relevant communicable diseases or incompatibility to blood markers, and microbiological screening of the collected tissues. An FDA - registered laboratory use FDA - approved test kits to perform the indicated tests, in compliance with the Clinical Laboratory Improvement Amendments of 1988 (CLIA) and the required laboratory requirements described in 42 CFR Part 493 .

Most labs in the United States buy from tissue banks that resale expanded cells. Our regenerative cells are not expanded. They are pure non-expanded cells. The products that Mirelle Medical Aesthetics uses are cryopreserved in a proprietary solution without DMSO and stored at -80 C or below.  The regenerative cells are harvested from the blood and Wharton Jelly from each individual umbilical cord in an FDA - compliant laboratory in accordance with Current Good Manufacturing Practices (CGMP), Current Good Tissue Practice (CGTP), and additional requirements for sterile allograft products processed in compliance with American Association of Tissue Banks (AATB) regulations.

Our product contains many factors that, in host, repair, and heal various trauma and disease states, falls into the ISCT criteria of MSC's and also contains growth factors that play a role in angiogenesis, growth, and repair of cartilage and bone tissue, which should serve well in orthopedic disease, and a wide array of autoimmune diseases.

Why umbilical cord regenerative cells?

Umbilical cord mesenchymal regenerative cells proliferate more quickly than MSC's from adipose tissue or bone marrow. They form significantly more bone nodules in vitro than MSC's from adipose tissue or bone marrow. UC MSC's differentiate into significantly fewer adipocytes ( fat cells ) than MSC's from adipose tissue. UC MSC's has lower expression of HLA - DMA, HLA - DPB1, HLA - DRA than other sources of MSC's. Bone marrow MSC's had the highest expression. UC MSC's shows the highest inhibition of T cell proliferation of four MSC's sources.

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