Hormone Replacement Therapy explained by our esteemed colleague Dr. Anil Rajani.
Menopause & Andropause
The best time to be alive if your hormones are balanced
Hormone response is as unique to each person as their own fingerprints. Therefore, hormone replacement should not be considered without a thorough evaluation by a practitioner who is understanding the human physiology and the pharmacodynamics and interaction of the hormones in the human body.
Our philosophy is age reversal through hormonal balance and support.
Because the science of epigenetics is based on personalized and precise interventions aimed to change defective genetic pathways, we have developed partnerships with the most reputable specialized laboratories, manufacturers of pharmaceutical grade supplements, and health monitoring companies to fully support our patients on their journey toward anti-aging.
Why bio-identical hormone replacement therapy is a good idea for both men and women?
►Mental health ►Relief of symptoms ►Thyroid health ►Sexual health ►Prevention of memory loss ►Heart health ►Bone health ►Growth and repair ►Hair health ►Skin health ►Muscle health ►Anti-Aging
Bio-identical vs. Synthetic Hormones
Bio-identical hormones are chemically identical to the hormones produced by our bodies during the younger years. Often obtained from plants, the term “bio-identical” does not refer to plant-based or organic sources. It may or may not come from a plant. However, here are some pros’ and cons ‘to consider:
As the body ages, endogenous hormone production is diminished. Left unattended, the body is rapidly aging and deteriorating. When replenished, hormones maintain significant functions in the body and therefore the body ages at a much slower pace.
Estrogen is a hormone present in both genders is responsible for approximately 400 functions in the human body. When diminished, these 400 functions are being suppressed. Synthetic hormones often give confusing messages to our cells. Here are some functions of the Estrogen that cannot be gambled with:
►Stimulates the production of choline acetyltransferase, an enzyme which prevents Alzheimer’s disease ►Increases metabolic rate ►Improves insulin sensitivity ►Regulates body temperature ►Helps prevent muscle damage ►Helps maintain muscle ►Improves sleep 15 ►Reduces risk of cataracts ►Helps maintain the elasticity of arteries ►Dilates small arteries ►Increases blood flow ►Inhibits platelet stickiness ►Decreases the accumulation of plaque on arteries ►Enhances magnesium uptake and utilization ►Maintains the amount of collagen in the skin 16 ►Decreases blood pressure ►Decreases LDL and prevents its oxidation ►Helps maintain memory ►Increases reasoning and new ideas ►Helps with fine motor skills ►Increases the water content of skin and is responsible for its thickness and softness ►Enhances the production of nerve-growth factor ►Positive effect on emotions ►Increases HDL by 10 to 15% ►Reduces the overall risk of heart disease by 40 to 50% ►Decreases lipoprotein(a) ►Acts as a natural calcium channel blocker to keep arteries open ►Enhances energy ►Improves mood ►Increases concentration ►Maintains bone density ►Helps prevent glaucoma ►Increases sexual interest ►Reduces homocysteine ►Decreases wrinkles ►Protects against macular degeneration ►Decreases risk of colon cancer ►Helps prevent tooth loss ►Aids in the formation of neurotransmitters in the brain such as serotonin which decreases depression, irritability, anxiety, and pain sensitivity
Graham, B., et al., “Sex hormones are associated with rumination and interact with emotion regulation strategy choice to predict negative affect in women following a sad mood induction,” Front Psychol 2018; 9:937.
Often obtained from plants, the term “bio-identical” does not refer to plant-based or organic sources. It may or may not come from a plant. However, here are some pros’ and cons ‘to consider:
Help to protect against endothelial dysfunction by increasing endothelial nitric oxide. Endothelial nitric oxide synthase is a crucial enzyme involved in the production of nitric oxide in endothelial cells. Study showed that compared to natural estrogen, gene transcription of endothelial nitric oxide synthase was 30 to 50% lower in response to equine estrogens (Novensa, L., et al., “Equine estrogens impair nitric oxide production and endothelial nitric oxide synthase transcription in human endothelial cells compared with the natural 17(beta)-estradiol,” Hypertension 2010; 56(3):405- 11)
Progesterone is a sex hormone made from its precursor Pregnenolone. Some important functions of progesterone are:
►Acts as a diuretic and anti-inflammatory ► Aids in ovulation ►Balances estrogen ►Effects the potentiation of GABA ►Enhances the action of thyroid hormones ►Has a positive effect on sleep ►Helps build bone ►Helps maintain bladder function ►Maintains pregnancy ►Helps prevent anxiety, irritability, and mood swings ►Helps restore proper cell-oxygen levels ► Helps the body use and eliminate fats ► Increases metabolic rate ►Increases scalp hair ►Induces conversion of E1 to the inactive E1S form ►Lowers LDL ►Modulates oxytocin receptor binding in the hypothalamus ► Promotes Th2 immunity ►Protects breast health ►Relaxes smooth muscle of the gut to aid in breaking down food ►Supports the immune system ► Helps promote implantation of the egg ► Promotes the formation of myelin sheaths ►Protection against breast cancer
Studies indicate that women who were deficient in progesterone had 5.4x increased risk of developing premenopausal breast cancer and were10x as likely to die from any cancer.
Cowan, L., et al., “Breast cancer incidence in women with a history of progesterone deficiency,” Amer Jour Epidemiol 1981; 114(2):209-17.
DO NOT have the same chemical structure of the hormones that the body is born with. Most common synthetic hormone are estrogen and progestin. Synthetic hormones waste energy by giving incomplete messages to cells which then fail to produce a balanced hormonal response.
►Increases sexual interest ►Increases sense of emotional well-being ►Increases muscle mass and strength ►Helps maintain memory ►Helps skin from sagging ►Decreases excess body fat ►Helps maintain bone strength ►Elevates norepinephrine in the brain (tricyclic affect) ►Aids with pain control
It is important to use the bio-identical form of this hormone because the synthetic form Methyltestosterone has been associated with an increase in liver cancer.
Is a hormone made by the adrenal glands. A small amount is also made in the brain and skin. DHEA production declines with age starting in the late twenties. By the age of 70 the body may only make ¼ of the amount of DHEA it made earlier. DHEA makes estrogen and testosterone in both women and men. DHEA levels may also change due to stress at any age.
Functions of DHEA are:
Decreases cholesterol ► Decreases formation of fatty deposits ► Prevents blood clots ► Increases bone growth ► Promotes weight loss ► Increases brain function ► Increases lean body mass ► Increases sense of well-being ► Helps one deal with stress ► Supports the immune system ► Helps the body repair itself and maintain tissues ► Decreases allergic reactions ► Lowers triglycerides ► Increases insulin sensitivity ► In the elderly DHEA exerts an immunomodulatory action, increasing the number of monocytes, T cells expressing Tcell receptor gamma/delta (TCRγδ) and natural killer (NK) cells. ► It improves physical and psychological wellbeing, muscle strength, bone density, and reduces body fat and age-related skin atrophy stimulating procollagen/sebum production ► DHEA modulates cardiovascular, anti-inflammatory, vasorelaxant and anti-remodeling effect ►DHEA/DHEAS appear protective in asthma and allergy by attenuating T helper 2 allergic inflammation and reducing eosinophilia and airway hyperreactivity ►In women DHEA improves sexual satisfaction, fertility and age-related vaginal atrophy.
Rutkowski, K., et al., Dehydroepiandrosterone (DHEA): hypes and hopes,” Drugs 2014; 74(11):1195-207.
Our clinic specializes in bio-identical hormone replacement therapy for both men and women. To ensure the quality and bioavailability of the hormones we provide to our patients, we are working with exclusive compounding pharmacies that are sure to provide authentic products. Often more expensive than some local compounders, they provide superior quality medication that is safe and effective for our patients.